Holliday follows the infamous 1880s gambler, dentist, and gunslinger, Doc Holliday. From the outset, Doc has been diagnosed with tuberculosis and is told to head to dryer climates and imbibe to prolong his life. He has also heard of a spring located somewhere along the frontier that could cure him—what he believes to be the mythical Fountain of Youth. The novel portrays Holliday as a rock star, a living legend, increasingly hounded by paparazzi, enamored by death, cards, booze, and women. Doc is a mixture of Clint Eastwood and Jim Morrison, and though he is able to help his friend, Wyatt Earp, exact revenge, his condition worsens, traveling from Arizona to Denver, and finally dying in a sanatorium in Colorado with his boots off. A slow and unfitting end for such a bombastic outlaw.